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Benign thyroid gland neoplasm

MedGen UID:
102306
•Concept ID:
C0154038
•
Neoplastic Process
Synonyms: Benign Neoplasm of the Thyroid; benign neoplasm of the thyroid; Benign Neoplasm of the Thyroid Gland; benign neoplasm of the thyroid gland; Benign Neoplasm of Thyroid; benign neoplasm of thyroid; Benign neoplasm of thyroid gland; Benign Neoplasm of Thyroid Gland; benign neoplasm of thyroid gland; Benign Neoplasm of Thyroid Glands; benign neoplasm of thyroid glands; Benign Thyroid Gland Neoplasm; benign thyroid gland neoplasm; Benign Thyroid Gland Tumor; benign thyroid gland tumor; benign thyroid gland tumour; Benign Thyroid Neoplasm; benign thyroid neoplasm; Benign Thyroid Neoplasm NOS; Benign Thyroid Tumor; benign thyroid tumor; benign thyroid tumour; Benign Tumor of the Thyroid; benign tumor of the thyroid; Benign Tumor of the Thyroid Gland; benign tumor of the thyroid gland; Benign Tumor of Thyroid; benign tumor of thyroid; Benign tumor of thyroid gland; Benign Tumor of Thyroid Gland; benign tumor of thyroid gland; benign tumour of the thyroid; benign tumour of the thyroid gland; benign tumour of thyroid; benign tumour of thyroid gland; thyroid gland benign neoplasm; Thyroid Neoplasm, Benign; thyroid neoplasm, benign
SNOMED CT: Benign tumor of thyroid gland (92439006); Benign neoplasm of thyroid gland (92439006)
 
Monarch Initiative: MONDO:0006107

Definition

A neoplasm that arises from the thyroid gland and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

2023 European Thyroid Association Clinical Practice Guidelines for thyroid nodule management.
Durante C, Hegedüs L, Czarniecka A, Paschke R, Russ G, Schmitt F, Soares P, Solymosi T, Papini E
Eur Thyroid J 2023 Oct 1;12(5) Epub 2023 Aug 14 doi: 10.1530/ETJ-23-0067. PMID: 37358008Free PMC Article
Contemporary Thyroid Nodule Evaluation and Management.
Grani G, Sponziello M, Pecce V, Ramundo V, Durante C
J Clin Endocrinol Metab 2020 Sep 1;105(9):2869-83. doi: 10.1210/clinem/dgaa322. PMID: 32491169Free PMC Article
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.
Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L
Thyroid 2016 Jan;26(1):1-133. doi: 10.1089/thy.2015.0020. PMID: 26462967Free PMC Article

Recent clinical studies

Etiology

Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach.
Jung CK, Bychkov A, Kakudo K
Endocrinol Metab (Seoul) 2022 Oct;37(5):703-718. Epub 2022 Oct 4 doi: 10.3803/EnM.2022.1553. PMID: 36193717Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Contemporary Management of Thyroid Nodules.
Kobaly K, Kim CS, Mandel SJ
Annu Rev Med 2022 Jan 27;73:517-528. Epub 2021 Aug 20 doi: 10.1146/annurev-med-042220-015032. PMID: 34416120
Preoperative Molecular Testing of Thyroid Nodules: Current Concepts.
Williams MD
Neuroimaging Clin N Am 2021 Aug;31(3):301-312. doi: 10.1016/j.nic.2021.04.009. PMID: 34243865
Decision Making in Indeterminate Thyroid Nodules and the Role of Molecular Testing.
Mitchell J, Yip L
Surg Clin North Am 2019 Aug;99(4):587-598. Epub 2019 May 9 doi: 10.1016/j.suc.2019.04.002. PMID: 31255193

Diagnosis

Changes in thyroid cytology reporting in the 3rd edition of the Bethesda system.
J D
Cesk Patol 2024;60(1):64-67. PMID: 38697829
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Decision Making in Indeterminate Thyroid Nodules and the Role of Molecular Testing.
Mitchell J, Yip L
Surg Clin North Am 2019 Aug;99(4):587-598. Epub 2019 May 9 doi: 10.1016/j.suc.2019.04.002. PMID: 31255193
Survivin as a diagnostic and therapeutic marker for thyroid cancer.
Mahmoudian-Sani MR, Alghasi A, Saeedi-Boroujeni A, Jalali A, Jamshidi M, Khodadadi A
Pathol Res Pract 2019 Apr;215(4):619-625. Epub 2019 Jan 18 doi: 10.1016/j.prp.2019.01.025. PMID: 30683476
Role of ultrasonography in thyroid disease.
Sheth S
Otolaryngol Clin North Am 2010 Apr;43(2):239-55, vii. doi: 10.1016/j.otc.2010.02.001. PMID: 20510712

Therapy

Role of Thyroid RFA in the Treatment of Autonomously Functioning Thyroid Nodules.
Sag AA, Kazaure HS, Kelley CE
Tech Vasc Interv Radiol 2022 Jun;25(2):100823. Epub 2022 Mar 12 doi: 10.1016/j.tvir.2022.100823. PMID: 35551806
Transoral thyroidectomy vestibular approach versus non-transoral endoscopic thyroidectomy: a comprehensive systematic review and meta-analysis.
Wang D, Wang Y, Zhou S, Liu X, Wei T, Zhu J, Li Z
Surg Endosc 2022 Mar;36(3):1739-1749. Epub 2021 Nov 8 doi: 10.1007/s00464-021-08836-w. PMID: 34750702
Radiofrequency ablation and thyroid nodules: updated systematic review.
Muhammad H, Santhanam P, Russell JO
Endocrine 2021 Jun;72(3):619-632. Epub 2021 Jan 15 doi: 10.1007/s12020-020-02598-6. PMID: 33449296
Radioactive iodine (RAI) therapy for metastatic differentiated thyroid cancer.
Verburg FA, Hänscheid H, Luster M
Best Pract Res Clin Endocrinol Metab 2017 Jun;31(3):279-290. Epub 2017 May 9 doi: 10.1016/j.beem.2017.04.010. PMID: 28911724
Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer.
American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer, Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F, Schlumberger M, Sherman SI, Steward DL, Tuttle RM
Thyroid 2009 Nov;19(11):1167-214. doi: 10.1089/thy.2009.0110. PMID: 19860577

Prognosis

Thyroid metastasis of vaginal leiomyosarcoma: a case report and review of the literature.
Golovko A, Kuryk O *, Tkachenko R, Mendel N
Exp Oncol 2020 Sep;42(3):242-244. doi: 10.32471/exp-oncology.2312-8852.vol-42-no-3.15029. PMID: 32996738
Thyroid nodules - investigation and follow-up.
Tangerud Å, Sigstad E, Fagerlid KH, Paulsen TH, Norheim I
Tidsskr Nor Laegeforen 2020 Sep 8;140(12) Epub 2020 Sep 3 doi: 10.4045/tidsskr.20.0186. PMID: 32900166
Radioactive iodine (RAI) therapy for metastatic differentiated thyroid cancer.
Verburg FA, Hänscheid H, Luster M
Best Pract Res Clin Endocrinol Metab 2017 Jun;31(3):279-290. Epub 2017 May 9 doi: 10.1016/j.beem.2017.04.010. PMID: 28911724
The melanoma 'epidemic': lessons from prostate cancer.
Glusac EJ
J Cutan Pathol 2012 Jan;39(1):17-20. doi: 10.1111/j.1600-0560.2011.01848.x. PMID: 22211331
Management of follicular tumors of the thyroid.
Wang TS, Roman SA, Sosa JA
Minerva Chir 2007 Oct;62(5):373-82. PMID: 17947948

Clinical prediction guides

Thyroid Nodules: Advances in Evaluation and Management.
Kant R, Davis A, Verma V
Am Fam Physician 2020 Sep 1;102(5):298-304. PMID: 32866364
The 2017 Bethesda System for Reporting Thyroid Cytopathology.
Cibas ES, Ali SZ
Thyroid 2017 Nov;27(11):1341-1346. doi: 10.1089/thy.2017.0500. PMID: 29091573
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.
Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L
Thyroid 2016 Jan;26(1):1-133. doi: 10.1089/thy.2015.0020. PMID: 26462967Free PMC Article
The value of ultrasound elastography in differentiation of malignancy in thyroid nodules.
Akcay MA, Semiz-Oysu A, Ahiskali R, Aribal E
Clin Imaging 2014 Mar-Apr;38(2):100-3. Epub 2013 Nov 26 doi: 10.1016/j.clinimag.2013.11.008. PMID: 24387918
Thyroid nodule shape suggests malignancy.
Cappelli C, Castellano M, Pirola I, Gandossi E, De Martino E, Cumetti D, Agosti B, Rosei EA
Eur J Endocrinol 2006 Jul;155(1):27-31. doi: 10.1530/eje.1.02177. PMID: 16793946

Recent systematic reviews

Pituitary Adenoma in the Philippines: A Scoping Review on the Treatment Gaps, Challenges, and Current State of Care.
Tabuzo MMB, Hernandez MALU, Chua AE, Maningat PD, Chiu HHC, Jamora RDG
Med Sci (Basel) 2024 Mar 19;12(1) doi: 10.3390/medsci12010016. PMID: 38535157Free PMC Article
Transoral thyroidectomy vestibular approach versus non-transoral endoscopic thyroidectomy: a comprehensive systematic review and meta-analysis.
Wang D, Wang Y, Zhou S, Liu X, Wei T, Zhu J, Li Z
Surg Endosc 2022 Mar;36(3):1739-1749. Epub 2021 Nov 8 doi: 10.1007/s00464-021-08836-w. PMID: 34750702
Radiofrequency ablation and thyroid nodules: updated systematic review.
Muhammad H, Santhanam P, Russell JO
Endocrine 2021 Jun;72(3):619-632. Epub 2021 Jan 15 doi: 10.1007/s12020-020-02598-6. PMID: 33449296
The role of elastography in evaluating thyroid nodules: a literature review and meta-analysis.
Veer V, Puttagunta S
Eur Arch Otorhinolaryngol 2015 Aug;272(8):1845-55. Epub 2014 Jul 6 doi: 10.1007/s00405-014-3155-7. PMID: 24997982
Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria.
Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E
J Natl Cancer Inst 2013 Nov 6;105(21):1607-16. Epub 2013 Oct 17 doi: 10.1093/jnci/djt277. PMID: 24136893

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